[태그:] diagnosis

While Kras mutation cooperated with loss of p53 or Ink4a/Arf (CDKN2A ), in this system, the strongest cooperation was observed with homozygous inactivation of Lkb1. Lkb1-deficient tumors demonstrated shorter latency, an expanded histologic spectrum (adeno-, squamous, and substantial-cell carcinoma), and a lot more frequent metastasis compared to tumors lacking p53 or Ink4a/Arf. Pulmonary tumorigenesis was also accelerated by hemizygous inactivation of Lkb1. Newer sorts of immunotherapy may perhaps lead to…Read More